血根碱
血根碱用途
血根碱名称
[ CAS 号 ]:
2447-54-3
[ 中文名 ]:
血根碱
[ 英文名 ]:
SANGUINARINE
[中文别名 ]:
[英文别名 ]:
- Sanguinarin
- sanquinarine
- SANGUINARINE
- y-Chelerythrine
- EINECS 219-503-3
- Sanguinarine Chloride
- sanguninarine
- Dimethylenedioxy benzphenanthridine
- Pseudochelerythrine
血根碱生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Apoptosis[1]
[体外研究]
[体内研究]
[激酶实验]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
血根碱物理化学性质
[ 密度 ]:
1.3463 (rough estimate)
[ 沸点 ]:
483.53°C (rough estimate)
[ 熔点 ]:
205-215ºC
[ 分子式 ]:
C20H14NO4
[ 分子量 ]:
332.329
[ 精确质量 ]:
332.091736
[ PSA ]:
40.80000
[ LogP ]:
3.42810
[ 折射率 ]:
1.5180 (estimate)
[ 储存条件 ]:
室温,干燥
血根碱毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VP5200000
- CHEMICAL NAME :
- Sanguinarine
- CAS REGISTRY NUMBER :
- 2447-54-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C20-H14-N-O4
- MOLECULAR WEIGHT :
- 332.35
- WISWESSER LINE NOTATION :
- T H5 F6 E6 B665 DK IO KO VO A&OT&&&&TJ DQ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1660 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,176,1985
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2200 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,176,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IJCAAR Indian Journal of Cancer. (Indian Cancer Soc., Parel, Bombay, 400 012, India) V.1- 1963- Volume(issue)/page/year: 5,183,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,176,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),195,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19400 ug/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 29,76,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960
血根碱安全信息
[ 风险声明 (欧洲) ]:
R25
[ 安全声明 (欧洲) ]:
13-45
[ 危险品运输编码 ]:
UN 1544
血根碱合成路线
血根碱上下游产品
血根碱上游产品
血根碱下游产品
相关药品:
推荐生产厂家/供应商:
公司名:云南西力生物技术股份有限公司
区域:昆明市盘龙区
价格:
¥需询单/20mg
联系人:郑雪平
产品详情:血根碱
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥1600.0/5mg
联系人:刘佳
产品详情:血根碱
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥1489.0/20mg
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Sanguinarine
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥743.0/100mg
¥1470.0/20mg
联系人:夏言
产品详情:[Perfemiker]血根碱,98%
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥269.9/25mg
¥205.9/1ml
¥799.9/100mg
¥5099.9/1g
联系人:阿拉丁
产品详情:血根碱
查看所有供应商请点击:
相关化合物
【血根碱】化源网提供血根碱CAS号2447-54-3,血根碱MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询血根碱上化源网,专业又轻松。>>电脑版:血根碱
标题:血根碱_用途_密度_熔点_血根碱CAS号【2447-54-3】_化源网 地址:https://www.chemsrc.com/amp/cas/2447-54-3_684618.html