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原阿片碱

原阿片碱用途

原阿片碱 (Protopine) 是一种异喹啉类生物碱,常存在于亚洲东北部的一些植物中,主要用于抗肿瘤、抗炎活性的研究。

原阿片碱名称

[ CAS 号 ]:
130-86-9

[ 中文名 ]:
原阿片碱

[ 英文名 ]:
Protopine

[中文别名 ]:

[英文别名 ]:

Protopine
Biflorine
Protopin
EINECS 204-999-6
BIFLORIN
Hypercorine
4,6,7,14-Tetrahydro-5-Methyl
Tangeratin
Corydinine
Corydalis C

原阿片碱生物活性

[ 描述 ]:

原阿片碱 (Protopine) 是一种异喹啉类生物碱,常存在于亚洲东北部的一些植物中,主要用于抗肿瘤、抗炎活性的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 其他

[参考文献]

[1]. Bae DS, et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 2012 Feb;45(2):108-13.

[2]. Chen CH, et al. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012 Feb 1;315(1):1-11.

[3]. Vrba J, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41.

[4]. He K, et al. Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24.

[相关活性小分子]

原阿片碱物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
547.5±49.0 °C at 760 mmHg

[ 熔点 ]:
211ºC

[ 分子式 ]:
C₂₀H₁₉NO₅

[ 分子量 ]:
353.369

[ 闪点 ]:
284.9±29.8 °C

[ 精确质量 ]:
353.126312

[ PSA ]:
57.23000

[ LogP ]:
3.76

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
水溶性：不溶；水溶解度：8.99 mg/l 25 °C；可溶于：氯仿；微溶：乙醇,苯；极微溶：乙醚,醇

原阿片碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS2800000

CAS REGISTRY NUMBER :: 130-86-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H19-N-O5

MOLECULAR WEIGHT :: 353.40

WISWESSER LINE NOTATION :: T I5 F6 C-10-65 DV JO LO PN VO A&O KH&&T&&J P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,24,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 482 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(6),7,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,640,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 237 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 28,767,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 28,767,1973

原阿片碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310 + P330

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
VS2800000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

原阿片碱

原阿片碱用途

原阿片碱名称

原阿片碱生物活性

原阿片碱物理化学性质

原阿片碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

原阿片碱安全信息

原阿片碱合成路线

详细合成路线

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