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2,4-二氯苄醇

2,4-二氯苄醇用途

2,4-Dichlorobenzyl alcohol 是一种温和的杀菌剂,对口腔和咽喉感染的细菌和病毒有广泛的抗病毒作用。

2,4-二氯苄醇名称

[ CAS 号 ]:
1777-82-8

[ 中文名 ]:
2,4-二氯苄醇

[ 英文名 ]:
2,4-DICHLOROBENZYLALCOHOL

[中文别名 ]:

[英文别名 ]:

MFCD00004606
2,4-dichlorbenzyl alcohol
EINECS 217-210-5
Benzenemethanol, 2,4-dichloro-
Benzenemethanol,2,4-dichloro
2,4-Dichlorobenzyl alcohol
2,4-DICHLOROBENZYLALCOHOL
(2,4-Dichlorophenyl)methanol

2,4-二氯苄醇生物活性

[ 描述 ]:

2,4-Dichlorobenzyl alcohol 是一种温和的杀菌剂,对口腔和咽喉感染的细菌和病毒有广泛的抗病毒作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Morokutti-Kurz M , et al. Amylmetacresol/2,4-dichlorobenzyl alcohol, hexylresorcinol, or carrageenan lozenges as active treatments for sore throat. Int J Gen Med. 2017 Feb 28;10:53-60.

[2]. Matthews D, et al. Spectrum of bactericidal action of amylmetacresol/2,4-dichlorobenzyl alcohol lozenges against oropharyngeal organisms implicated in pharyngitis. Int J Gen Med. 2018 Nov 28;11:451-456.

2,4-二氯苄醇物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
268.4±25.0 °C at 760 mmHg

[ 熔点 ]:
55-58 °C(lit.)

[ 分子式 ]:
C₇H₆Cl₂O

[ 分子量 ]:
177.028

[ 闪点 ]:
115.0±17.2 °C

[ 精确质量 ]:
175.979568

[ PSA ]:
20.23000

[ LogP ]:
2.24

[ 外观性状 ]:
白色-淡黄色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
2-8°C

2,4-二氯苄醇MSDS

2,4-二氯苄醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO0890000

CHEMICAL NAME :: Benzyl alcohol, 2,4-dichloro-

CAS REGISTRY NUMBER :: 1777-82-8

BEILSTEIN REFERENCE NO. :: 1448652

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H6-Cl2-O

MOLECULAR WEIGHT :: 177.03

WISWESSER LINE NOTATION :: Q1R BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 95(6),59,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 95(6),59,1980

2,4-二氯苄醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DO0890000

[ 海关编码 ]:
29062900

2,4-二氯苄醇合成路线

2,4-二氯苄醇上下游产品

2,4-二氯苄醇上游产品

2,4-二氯苄醇下游产品

2,4-二氯苄醇制备

1.苯甲醇在浓盐酸存在下与氯气发生加成反应制得。

2,4-二氯苄醇海关

[ 海关编码 ]: 2906299090

[ 中文概述 ]:
2906299090 其他芳香醇. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2,4-二氯苄醇文献

Open-label taste-testing study to evaluate the acceptability of both strawberry-flavored and orange-flavored amylmetacresol/2,4-dichlorobenzyl alcohol throat lozenges in healthy children.

Drugs R. D. 13(2) , 101-7, (2013)

Acute sore throat (pharyngitis) is one of the most common illnesses for which children are seen by primary care physicians. Most cases are caused by viruses and are benign and self-limiting. Clinicall...

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