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异丁芬酸

异丁芬酸用途

伊布芬酸(Dytransin)是一种非甾体类抗类风湿药物,可以用作镇痛和抗炎剂[1]。

异丁芬酸名称

[ CAS 号 ]:
1553-60-2

[ 中文名 ]:
异丁芬酸

[ 英文名 ]:
Ibufenac

[中文别名 ]:

4-异丁基苯乙酸

[英文别名 ]:

[4-(2-methylpropyl)phenyl]acetic acid
(p-isobutylphenyl)aceticacid
Benzeneacetic acid, 4-(2-methylpropyl)-
ibufenac
2-[4-(2-methylpropyl)phenyl]acetic acid
4-Isobutylphenylacetic acid
(4-Isobutylphenyl)acetic acid

异丁芬酸生物活性

[ 描述 ]:

伊布芬酸(Dytransin)是一种非甾体类抗类风湿药物,可以用作镇痛和抗炎剂[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. S S Adams, et al. Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent. J Pharm Pharmacol. 1968 Apr;20(4):305-12.

异丁芬酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
312.2±11.0 °C at 760 mmHg

[ 熔点 ]:
85-87ºC

[ 分子式 ]:
C₁₂H₁₆O₂

[ 分子量 ]:
192.254

[ 闪点 ]:
209.3±14.4 °C

[ 精确质量 ]:
192.115036

[ PSA ]:
37.30000

[ LogP ]:
3.38

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
2-8°C

异丁芬酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI4200000

CHEMICAL NAME :: Acetic acid, (p-isobutylphenyl)-

CAS REGISTRY NUMBER :: 1553-60-2

LAST UPDATED :: 199801

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H16-O2

MOLECULAR WEIGHT :: 192.28

WISWESSER LINE NOTATION :: QV1R D1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,481,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,22,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 200,271,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,481,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,22,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 29120 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 200,271,1963

异丁芬酸安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
AI4200000

[ 海关编码 ]:
2916399090

异丁芬酸合成路线

详细合成路线

异丁芬酸上下游产品

异丁芬酸上游产品

异丁芬酸下游产品

异丁芬酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%