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芦丁

芦丁用途

Rutin是天然的黄酮苷,具有抗炎,抗氧化、抗过敏、抗病毒等功效。

芦丁名称

[ CAS 号 ]:
153-18-4

[ 中文名 ]:
芸香叶苷

[ 英文名 ]:
Rutin

[中文别名 ]:

[英文别名 ]:

Tanrutin
Quercetin 3-O-β-D-rutinoside
Venoruton
Vitamin P trihydrate
Ilixathin
Quercetin 3-O-rutinoside
Quercetin 3-β-rutinoside
Rutinion acid
Osyritrin
Violaquercitrin

芦丁生物活性

[ 描述 ]:

Rutin是天然的黄酮苷,具有抗炎,抗氧化、抗过敏、抗病毒等功效。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[参考文献]

[1]. E. H. Aksu, et al. Rutin ameliorates cisplatin-induced reproductive damagevia suppression of oxidative stress and apoptosis in adultmale rats. Andrologia. 2016 Apr 23.

[2]. Han YH, et al. Lipin1-Mediated Repression of Adipogenesis by Rutin.Am J Chin Med. 2016;44(3):565-78

[3]. Lu N, et al. Effects of rutin on the redox reactions of hemoglobin. Int J Biol Macromol. 2016 Apr 25;89:175-180.

[相关活性小分子]

芦丁物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
983.1±65.0 °C at 760 mmHg

[ 熔点 ]:
195 °C (dec.)(lit.)

[ 分子式 ]:
C₂₇H₃₀O₁₆

[ 分子量 ]:
610.518

[ 闪点 ]:
325.4±27.8 °C

[ 精确质量 ]:
610.153381

[ PSA ]:
269.43000

[ LogP ]:
1.76

[ 外观性状 ]:
灰白-黄色结晶固体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.765

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ 水溶解性 ]:
12.5 g/100 mL

芦丁MSDS

详细MSDS(安全技术说明书)

芦丁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VM2975000

CHEMICAL NAME :: Rutin

CAS REGISTRY NUMBER :: 153-18-4

BEILSTEIN REFERENCE NO. :: 0075455

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C27-H30-O16

MOLECULAR WEIGHT :: 610.57

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 973 gm/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Body fluid assay

TEST SYSTEM :: Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 gm/kg

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,9,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80506 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80506 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

芦丁安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
3

[ RTECS号 ]:
VM2975000

[ 海关编码 ]:
2932999099

芦丁上下游产品

芦丁上游产品

芦丁下游产品

芦丁制备

1. 芸香苷存在于芸香叶、烟叶、橙皮、番茄等内，槐花米和荞麦花内含量尤其丰富。我国药用的芸香苷是从槐花米中提得。槐花米经洗涤后，用热水和石灰乳（调pH至7.5-8）煮沸20min，添加硼砂，在95-100℃保温半小时，趁热过滤，用盐酸将滤液调至pH6-7，冷却至30℃以下，静置析出结晶，分离，得芸香苷粗品，经溶解、再结晶、干燥即得成品。以槐花米计总收率8.3%。

2. 将原料(一般用槐花蕾)粉碎后，用热乙醇萃取，再经乙醚、热甲醇和热水多次结晶精制而得。
浸提物浓缩后所得的残留物，用溶剂将其他可溶性色素等不纯物除去后，再经乙醇、乙醚、热甲醇和热水多次结晶和活性炭精制而得高纯度物。

芦丁海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

芦丁