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4'-氯地西泮

4'-氯地西泮用途

A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR).

4'-氯地西泮名称

[ CAS 号 ]:
14439-61-3

[ 中文名 ]:
4'-氯地西泮

[ 英文名 ]:
4'-Chlorodiazepam

[英文别名 ]:

Chlorodiazepam
4'-Chlorodiazepam
Ro-5-4864

4'-氯地西泮物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
517.1ºC at 760mmHg

[ 熔点 ]:
160-163ºC

[ 分子式 ]:
C₁₆H₁₂Cl₂N₂O

[ 分子量 ]:
319.18500

[ 闪点 ]:
266.6ºC

[ 精确质量 ]:
318.03300

[ PSA ]:
32.67000

[ LogP ]:
3.30780

[ 蒸汽压 ]:
8.43E-11mmHg at 25°C

[ 折射率 ]:
1.647

[ 储存条件 ]:
2-8℃，干燥，密闭

4'-氯地西泮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF0500000

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-

CAS REGISTRY NUMBER :: 14439-61-3

BEILSTEIN REFERENCE NO. :: 0685202

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-Cl2-N2-O

MOLECULAR WEIGHT :: 319.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990

4'-氯地西泮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
DF0500000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

4'-氯地西泮合成路线

详细合成路线

4'-氯地西泮上下游产品

4'-氯地西泮上游产品

4'-氯地西泮下游产品

4'-氯地西泮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4'-氯地西泮文献

Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

J. Med. Chem. 49 , 5845-8, (2006)

Cultured rat astrocytes and C6 rat glioma were used as a differential screen for a variety of 1,2,3,4-tetrahydroisoquinoline (THI) derivatives. Compound 1 [1-(biphenyl-4-ylmethyl)-1,2,3,4-tetrahydrois...

Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.

Life Sci. 92(6-7) , 345-51, (2013)

This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity.Gene expression analyse...

Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.

Biochem. Pharmacol. 97 , 99-110, (2015)

As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm...

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