SR 1903

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
559.0±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₂₇F₆N₃O

[ 分子量 ]:
523.513

[ 闪点 ]:
291.9±30.1 °C

[ 精确质量 ]:
523.205811

[ LogP ]:
4.74

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.550

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥2842.0/10mg ￥1696.0/5mg ￥451.0/1mg ￥需询单/1g

联系人：李先生

产品详情：SR 1903

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