1414248-06-8

• 常用中文名：SR 1903
• 常用英文名：SR 1903
• CAS号：1414248-06-8
• 分子式：C₂₇H₂₇F₆N₃O
• 分子量：523.513
• 发布时间：2021-01-13 19:33:01
• 更新时间：2024-01-17 18:41:34
• SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

名称

• 英文名: SR 1903
• 英文别名: SR 1903; 1,1,1,3,3,3-Hexafluoro-2-(2'-methyl-4'-{[4-(4-pyridinylmethyl)-1-piperazinyl]methyl}-4-biphenylyl)-2-propanol; [1,1'-Biphenyl]-4-methanol, 2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 559.0±50.0 °C at 760 mmHg
• 分子式: C₂₇H₂₇F₆N₃O
• 分子量: 523.513
• 闪点: 291.9±30.1 °C
• 精确质量: 523.205811
• LogP: 4.74
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.550