氯化两面针碱

氯化两面针碱用途

Nitidine chloride 是可从Zanthoxylum nitidum (Roxb) DC 中分离得到一种具有抗疟疾活性的化合物。Nitidine chloride 通过多个靶点通路,发挥抗癌活性,如诱导凋亡,抑制STAT3、DNA拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。Nitidine chloride通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。

氯化两面针碱名称

[ CAS 号 ]:
13063-04-2

[ 中文名 ]:
氯化两面针碱

[ 英文名 ]:
Nitidine chloride

[中文别名 ]:

光叶花椒碱

[英文别名 ]:

Nitidine chloride

氯化两面针碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 干细胞及 Wnt 通路 >> STAT

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

信号通路 >> JAK/STAT信号通路 >> STAT

信号通路 >> 蛋白酪氨酸激酶 >> FAK

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 炎症/免疫

信号通路 >> MAPK/ERK信号通路 >> ERK

信号通路 >> 干细胞及 Wnt 通路 >> ERK

[参考文献]

[1]. Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87.

[2]. Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50.

[3]. Pan X, et al. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27;313(2):181-91.

[4]. Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6.

[5]. Liu LM, et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. Int J Oncol. 2018 Nov;53(5):1897-1912.

[6]. Bouquet J, et al. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67.

氯化两面针碱物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
619ºC at 760 mmHg

[ 熔点 ]:
281-282ºC

[ 分子式 ]:
C₂₁H₁₈ClNO₄

[ 分子量 ]:
383.825

[ 闪点 ]:
189.4ºC

[ 精确质量 ]:
383.092438

[ PSA ]:
40.80000

[ LogP ]:
3.71660

[ 外观性状 ]:
white to beige

[ 蒸汽压 ]:
3.01E-15mmHg at 25°C

[ 折射率 ]:
1.696

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
DMSO: soluble1mg/mL, clear (warmed)

氯化两面针碱MSDS

详细MSDS(安全技术说明书)

氯化两面针碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF4935500

CHEMICAL NAME :: (1,3)-Benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride

CAS REGISTRY NUMBER :: 13063-04-2

LAST UPDATED :: 199410

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H18-N-O4.Cl

MOLECULAR WEIGHT :: 383.85

WISWESSER LINE NOTATION :: T G5 E6 B666 HO JO OK IHJ O1 SO1 TO1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 98980 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 40 ug/plate

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 66,1781,1977

氯化两面针碱安全信息

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DF4935500

[ 海关编码 ]:
2933990090

氯化两面针碱合成路线

详细合成路线

氯化两面针碱上下游产品

氯化两面针碱上游产品

氯化两面针碱下游产品

氯化两面针碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氯化两面针碱文献

Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway.

Int. J. Mol. Med. 32(1) , 79-84, (2013)

Signal transducer and activator of transcription 3 (STAT3) is persistently activated in cancer cells and contributes to malignant progression in various types of cancer. The Janus-activated kinase (JA...

Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale.

Planta Med. 68(6) , 534-8, (2002)

Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolate...

The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.

J. Pharm. Pharmacol. 50(11) , 1307-15, (1998)

The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but t...

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