二乙二醇二甲醚

二乙二醇二甲醚用途

【用途一】
用作溶剂，也用作无污染清洗剂、萃取剂、稀释剂等
【用途二】
用作溶剂，也用于制药工业
【用途三】
主要用作溶剂。在金属有机化合物合成、烷基化反应、缩聚反应和还原反应中用作碱金属氢氧化物的溶剂。
【用途四】
二乙二醇二甲醚（111-96-6）为非质子极性溶剂,可用于极性有机反应,阴离子聚合、配位离子聚合反应的溶剂,可作还原、烷基化和缩合等反应溶剂,还可作为格氏和类似合成的介质,也用作无污染清洗剂、萃取剂、稀释剂、医药助剂及树脂溶剂.
【用途五】
本品为非质子极性溶剂，可用于极性有机反应，阴离子聚合、配位离子聚合反应的溶剂，可作还原烷基化和缩合等反应溶剂，还可作为格氏和类似合成的介质，也用作无污染清洗剂、萃取剂、稀释剂、医药助剂及树脂溶剂。

二乙二醇二甲醚名称

[ CAS 号 ]:
111-96-6

[ 中文名 ]:
二乙二醇二甲醚

[ 英文名 ]:
diglyme

[中文别名 ]:

[英文别名 ]:

diethyleneglycol dimethylether
Bis(2-methoxyethyl) Ether
diethylene glycol dimethyl ether
1-methoxyethoxy-2-methoxyethoxyethane
Dimethylcarbitol
DEG dibenzoate
bis-(2-methoxy ethyl)-ether
MFCD00008503
1-Methoxy-2-(2-methoxyethoxy)ethane
Benzo flex 2-45

二乙二醇二甲醚物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
159.8±0.0 °C at 760 mmHg

[ 熔点 ]:
−64 °C(lit.)

[ 分子式 ]:
C₆H₁₄O₃

[ 分子量 ]:
134.174

[ 闪点 ]:
70.0±0.0 °C

[ 精确质量 ]:
134.094299

[ PSA ]:
27.69000

[ LogP ]:
-0.80

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
4.6 (vs air)

[ 蒸汽压 ]:
3.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.394

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May be air or light sensitive.

[ 水溶解性 ]:
Miscible

二乙二醇二甲醚MSDS

详细MSDS(安全技术说明书)

二乙二醇二甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KN3339000

CHEMICAL NAME :: Ether, bis(2-methoxyethyl)

CAS REGISTRY NUMBER :: 111-96-6

BEILSTEIN REFERENCE NO. :: 1736101

LAST UPDATED :: 199806

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C6-H14-O3

MOLECULAR WEIGHT :: 134.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - maternal-fetal exchange

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13680 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1100 ppm/6H

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 537 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1000 ppm/5D (Continuous)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-138198 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0698 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 191 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0698 No. of Facilities: 13 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 207 (estimated) No. of Female Employees: 52 (estimated)

二乙二醇二甲醚安全信息

[ 符号 ]:

GHS02, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H360

[ 补充危害声明 ]:
May form explosive peroxides.

[ 警示性声明 ]:
P201-P210-P280-P308 + P313-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R10;R19;R60;R61

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 3271 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
KN3339000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2909199090

二乙二醇二甲醚合成路线

详细合成路线

二乙二醇二甲醚上下游产品

二乙二醇二甲醚上游产品

二乙二醇二甲醚下游产品

二乙二醇二甲醚制备

1.由一缩二乙醇与甲醇反应而得。也可由二乙二醇单甲醚与氯甲烷（或硫酸二甲酯）反应而得。

精制方法：可先用粒状氢氧化钠干燥，然后在氢化钙、氢化铝锂、氢化硼钠或氢化钠存在下回流、减压蒸馏精制。操作要在氮气流中进行。若二甘醇二甲醚有类似胺的气味，可在干燥和蒸馏前将它与弱酸性离子交换树脂一起振摇除去。保存时加入0.01%的氢化硼钠，以防止过氧化物生成。

二乙二醇二甲醚海关

[ 海关编码 ]: 2909199090

[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

二乙二醇二甲醚文献

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The risk-benefit balance for carbon nanotubes (CNTs) dictates their clinical fate. To take a step forward at this crossroad it is compulsory to modulate the CNT in vivo biocompatibility and biodegrada...

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Salts of highly fluorinated weakly coordinating anions as versatile precursors towards hydrogen storage materials.

Dalton Trans. 44 , 19469-77, (2015)

We report the most recent results related to application of a metathetic pathway towards mixed-metal borohydrides. The synthetic protocol utilizes highly-fluorinated weakly coordinating anion salts as...

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