盐酸去甲乌药碱

盐酸去甲乌药碱用途

Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。

盐酸去甲乌药碱名称

[ CAS 号 ]:
11041-94-4

[ 中文名 ]:
盐酸去甲乌头碱

[ 英文名 ]:
Higenamine HCl

[中文别名 ]:

[英文别名 ]:

Higenamine HCl
UNII:PQ432PID6E

盐酸去甲乌药碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 内分泌

[ 靶点 ]

β2-AR[1]

[参考文献]

[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

[2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

盐酸去甲乌药碱物理化学性质

[ 沸点 ]:
522.4ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₈ClNO₃

[ 分子量 ]:
307.772

[ 闪点 ]:
209.6ºC

[ 精确质量 ]:
307.097534

[ PSA ]:
72.72000

[ LogP ]:
3.36370

[ 蒸汽压 ]:
1.56E-11mmHg at 25°C

[ 储存条件 ]:
室温，干燥

盐酸去甲乌药碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX0484380

CHEMICAL NAME :: 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 11041-94-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H17-N-O3.Cl-H

MOLECULAR WEIGHT :: 307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

盐酸去甲乌药碱安全信息

[ 海关编码 ]:
2933499090

盐酸去甲乌药碱合成路线

详细合成路线

盐酸去甲乌药碱上下游产品

盐酸去甲乌药碱上游产品

盐酸去甲乌药碱下游产品

盐酸去甲乌药碱海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%