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11041-94-4生产厂家

11041-94-4价格

11041-94-4

11041-94-4结构式
11041-94-4结构式
  • 常用中文名:盐酸去甲乌药碱
  • 常用英文名:Higenamine HCl
  • CAS号:11041-94-4
  • 分子式:C16H18ClNO3
  • 分子量:307.772
  • 相关类别: 生物化工 植物提取物
  • 发布时间:2018-02-22 08:00:00
  • 更新时间:2024-01-02 14:42:25
  • Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。

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中文名 盐酸去甲乌头碱
英文名 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
中文别名 1-(4-羟基苄基)-6,7-二羟基-1,2,3,4-四氢异喹啉盐酸盐
盐酸去甲乌药碱
去甲乌药碱盐酸盐
6,7-二羟基-1-(4-羟基苄基)-1,2,3,4-四氢异喹啉盐酸盐
英文别名 pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one
1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1)
6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
Higenamine HCl
UNII:PQ432PID6E
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)
描述 Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。
相关类别
靶点

β2-AR[1]

参考文献

[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

[2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

沸点 522.4ºC at 760 mmHg
分子式 C16H18ClNO3
分子量 307.772
闪点 209.6ºC
精确质量 307.097534
PSA 72.72000
LogP 3.36370
蒸汽压 1.56E-11mmHg at 25°C
储存条件 室温,干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX0484380
CHEMICAL NAME :
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-
CAS REGISTRY NUMBER :
11041-94-4
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H17-N-O3.Cl-H
MOLECULAR WEIGHT :
307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

海关编码 2933499090

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11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

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11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

~%

11041-94-4结构式

11041-94-4

文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029
海关编码 2933499090
中文概述 2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%