Desmethyl Sibutramine hydrochloride

Modify Date: 2024-01-09 17:45:02

Desmethyl Sibutramine hydrochloride structure	Common Name	Desmethyl Sibutramine hydrochloride
	CAS Number	84467-94-7	Molecular Weight	302.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₅Cl₂N	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Desmethyl Sibutramine hydrochloride

Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4].

Name	1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine,hydrochloride
Synonym	More Synonyms

Description	Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
Target	NET and SERT[1]
References	[1]. Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. [2]. Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34. [3]. Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30. [4]. Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257.

Molecular Formula	C₁₆H₂₅Cl₂N
Molecular Weight	302.28
Exact Mass	301.13600
PSA	12.03000
LogP	5.58870

RIDADR	NONH for all modes of transport

N-Desmethylsibutramine hydrochloridehydrochloride

Desmethyl Sibutramine,Hydrochloride Salt

Desmethylsibutramine hydrochloride

mono-Desmethylsibutramine hydrochloride

Desmethyl Sibutramine hydrochloride

Use of Desmethyl Sibutramine hydrochloride

Names

Desmethyl Sibutramine hydrochloride Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms