α,β-Methylene-ATP

Modify Date: 2024-01-11 08:33:29

α,β-Methylene-ATP Structure
α,β-Methylene-ATP structure
Common Name α,β-Methylene-ATP
CAS Number 7292-42-4 Molecular Weight 505.20800
Density 2.5g/cm3 Boiling Point 968.2ºC at 760 mmHg
Molecular Formula C11H18N5O12P3 Melting Point N/A
MSDS N/A Flash Point 539.3ºC

 Use of α,β-Methylene-ATP


α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].

 Names

Name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
Synonym More Synonyms

 α,β-Methylene-ATP Biological Activity

Description α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].
Related Catalog
References

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1).  

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83  

 Chemical & Physical Properties

Density 2.5g/cm3
Boiling Point 968.2ºC at 760 mmHg
Molecular Formula C11H18N5O12P3
Molecular Weight 505.20800
Flash Point 539.3ºC
Exact Mass 505.01600
PSA 299.33000
Index of Refraction 1.887

 Synonyms

Adenosine 5'-[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate
Einecs 230-723-9
α,β-Methyleneadenosine 5'-triphosphate trisodium salt
adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate]
Adenosine-5'-methylenediphosphono-P2-phosphate
5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine
α,β-Methyleneadenosine5'-triphosphatetrisodiumsalt
Adenosine 5'-[[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate]
(α,β-Methylene)adenosine triphosphate