7292-42-4

7292-42-4 structure

Name: α,β-Methylene-ATP
Chemical Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
CAS Number: 7292-42-4
Molecular Formula: C₁₁H₁₈N₅O₁₂P₃
Molecular Weight: 505.20800
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2016-04-25 22:15:20
Modify Date: 2024-01-11 08:33:29
α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].

Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
Synonyms	Adenosine 5'-[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate Einecs 230-723-9 α,β-Methyleneadenosine 5'-triphosphate trisodium salt adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] Adenosine-5'-methylenediphosphono-P2-phosphate 5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine α,β-Methyleneadenosine5'-triphosphatetrisodiumsalt Adenosine 5'-[[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate] (α,β-Methylene)adenosine triphosphate

Description	α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
References	[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1). [2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83