DL-Mevalonolactone-d3

Modify Date: 2024-01-07 18:51:22

DL-Mevalonolactone-d3 structure	Common Name	DL-Mevalonolactone-d3
	CAS Number	61219-76-9	Molecular Weight	133.16000
	Density	N/A	Boiling Point	150ºC5 mm Hg(lit.)
	Molecular Formula	C₆H₇D₃O₃	Melting Point	28ºC(lit.)
	MSDS	N/A	Flash Point	N/A

Use of DL-Mevalonolactone-d3

DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].

Name	D,L-Mevalonic Acid Lactone-d3
Synonym	More Synonyms

Description	DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [3]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep108:133-145.

Boiling Point	150ºC5 mm Hg(lit.)
Melting Point	28ºC(lit.)
Molecular Formula	C₆H₇D₃O₃
Molecular Weight	133.16000
Exact Mass	133.08200
PSA	46.53000
LogP	0.07440

Precursor 7
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