WAY-388264-A
Modify Date: 2024-02-04 17:41:23
WAY-388264-A structure
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Common Name | WAY-388264-A | ||
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| CAS Number | 393129-91-4 | Molecular Weight | 296.17 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H14BrN5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WAY-388264-A5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2]. |
| Name | 5-HT2B antagonist-1 |
|---|
| Description | 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2]. |
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| Related Catalog | |
| Target |
5-HT2B Receptor:33.4 nM (IC50) |
| In Vitro | 5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM[1]. 5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines[3]. |
| In Vivo | 5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats[2]. |
| References |
| Molecular Formula | C11H14BrN5 |
|---|---|
| Molecular Weight | 296.17 |
| Storage condition | 2-8°C |