Muscimol hydrochloride
Modify Date: 2023-01-18 20:02:40
Muscimol hydrochloride structure
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Common Name | Muscimol hydrochloride | ||
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| CAS Number | 3579-03-1 | Molecular Weight | 150.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H7ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Muscimol hydrochlorideMuscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1]. |
| Name | 5-(aminomethyl)isoxazol-3-ol hydrochloride |
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| Description | Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1]. |
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| Related Catalog | |
| Target |
EC50: 0.2 μM (GABACreceptors)[1] |
| In Vivo | Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响[2]。 Muscimol 影响前扣带皮层 (ACC) 的微量调节，并且在 10 秒微量组中（62.5 或 125 µg/侧）对抑制噪声刺激没有影响[3]。 Animal Model: Female rhesus monkeys (Macaca mulatta) (5 kg and 5.5 kg)[2] Dosage: 1 μL, 5 μg/μL Administration: Implanted drug delivery tubes and infusion; single dose Result: Increased the error types and reaction time during the counting task. |
| References |
[1]. Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7. |
| Molecular Formula | C4H7ClN2O2 |
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| Molecular Weight | 150.56 |
| Exact Mass | 150.02000 |
| PSA | 72.28000 |
| LogP | 1.34120 |
| Precursor 0 | |
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| DownStream 1 | |
CAS#:2763-96-4