Aurora Kinases-IN-4

Modify Date: 2024-04-05 20:39:03

Aurora Kinases-IN-4 Structure
Aurora Kinases-IN-4 structure
Common Name Aurora Kinases-IN-4
CAS Number 2877011-84-0 Molecular Weight 468.55
Density N/A Boiling Point N/A
Molecular Formula C26H28N8O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aurora Kinases-IN-4


Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].

 Names

Name Aurora Kinases-IN-4

 Aurora Kinases-IN-4 Biological Activity

Description Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
Related Catalog
References

[1]. Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457.  

 Chemical & Physical Properties

Molecular Formula C26H28N8O
Molecular Weight 468.55
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