2877011-84-0

2877011-84-0 structure

Name: Aurora Kinases-IN-4
Chemical Name: Aurora Kinases-IN-4
CAS Number: 2877011-84-0
Molecular Formula: C₂₆H₂₈N₈O
Molecular Weight: 468.55
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2023-09-19 17:54:45
Modify Date: 2024-04-05 20:39:03
Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].

Name	Aurora Kinases-IN-4

Description	Aurora Kinases-IN-4 (Compound 11c) is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM). Aurora Kinases-IN-4 inhibits cell proliferation in SJSA-1, MDA-MB-231, A54, HeLa cells with IC50s of 4.27, 1.54, 3.08, 6.99 μM. Aurora Kinases-IN-4 can be used for research of triple negative breast cancer (TNBC)[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
References	[1]. Zhang B, et al. Discovery of a first-in-class Aurora A covalent inhibitor for the treatment of triple negative breast cancer. Eur J Med Chem. 2023 Aug 5;256:115457.

Molecular Formula	C₂₆H₂₈N₈O
Molecular Weight	468.55