YAP/TAZ inhibitor-2
Modify Date: 2024-01-05 15:42:59
YAP/TAZ inhibitor-2 structure
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Common Name | YAP/TAZ inhibitor-2 | ||
|---|---|---|---|---|
| CAS Number | 2762617-31-0 | Molecular Weight | 390.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14F4N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YAP/TAZ inhibitor-2YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1]. |
| Name | YAP/TAZ inhibitor-2 |
|---|
| Description | YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1]. |
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| Related Catalog | |
| Target |
EC50: 3 nM (TEAD-YAP/TAZ)[1] |
| In Vitro | YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1]. |
| In Vivo | YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1]. |
| References |
[1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1. |
| Molecular Formula | C19H14F4N4O |
|---|---|
| Molecular Weight | 390.33 |