SS47

Modify Date: 2024-01-23 11:34:04

SS47 structure	Common Name	SS47
	CAS Number	2636072-62-1	Molecular Weight	953.07
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₉H₅₆N₆O₁₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SS47

SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1].

Name	SS47

Description	SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Jingwen Si, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

Molecular Formula	C₄₉H₅₆N₆O₁₂S
Molecular Weight	953.07

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SS47

Use of SS47

Names

SS47 Biological Activity

Chemical & Physical Properties