Name | SS47 |
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Description | SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1]. |
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Related Catalog | |
References |
Molecular Formula | C49H56N6O12S |
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Molecular Weight | 953.07 |