SS47

Names

[ Name ]:
SS47

Biological Activity

[Description]:

SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Jingwen Si, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₅₆N₆O₁₂S

[ Molecular Weight ]:
953.07