CB1R Allosteric modulator 4
Modify Date: 2023-02-16 21:18:49
CB1R Allosteric modulator 4 structure
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Common Name | CB1R Allosteric modulator 4 | ||
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| CAS Number | 2633686-53-8 | Molecular Weight | 363.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H17N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CB1R Allosteric modulator 4CB1R Allosteric modulator 4 is a positive allosteric modulator of cannabinoid type-1 (CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment[1]. |
| Name | CB1R Allosteric modulator 4 |
|---|
| Description | CB1R Allosteric modulator 4 is a positive allosteric modulator of cannabinoid type-1 (CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment[1]. |
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| Related Catalog | |
| Target |
hCB1-R |
| In Vitro | CB1R is the most abundant G-protein coupled receptors (GPCR) in the CNS, CB1R involves in regulating physiological processes, from neurotransmission to energy metabolism[1]. CB1R Allosteric modulator 4 (compound 66b) (0.10 nM-10µM; 30 min) exerts inhibition of forskolin-stimulated cellular cAMP production in CHO hCB1R with an EC50 value of 0.05 μM[1]. CB1R Allosteric modulator 4 (0.10 nM-10µM; 90 min) acts function for β-arrestin-2 recruitment in hCB1R-CHO-K1 cells with an EC50 value of 0.163 μM[1]. CB1R Allosteric modulator 4 (1.6-200 µM; 2 h) improves aqueous solubility with good biological activity, and shows kinetic water solubility with solubility limit of 3.13 μM[1]. |
| References |
| Molecular Formula | C20H17N3O2S |
|---|---|
| Molecular Weight | 363.43 |