EZH2-IN-14

Modify Date: 2024-04-02 22:32:17

EZH2-IN-14 structure	Common Name	EZH2-IN-14
	CAS Number	1979157-17-9	Molecular Weight	541.69
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₉N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EZH2-IN-14

EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1].

Name	EZH2-IN-14

Description	EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
In Vitro	EZH2-IN-14 (C24) 有效减少H3K27me3 和 H3K27me2 蛋白水平，但对 MDA-MB-468 细胞中 EZH2 蛋白水平影响不大[1]。 Cell Viability Assay[1] Cell Line: MDA-MB-468 cells Concentration: 4 μM Incubation Time: 6 hours, 12 hours, 24 hours, 48 hours Result: Reduced the H3K27me3 and H3K27me2 marks.
References	[1]. Anqi Ma, et al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.

Molecular Formula	C₃₁H₃₉N₇O₂
Molecular Weight	541.69

EZH2-IN-14

Use of EZH2-IN-14

Names

EZH2-IN-14 Biological Activity

Chemical & Physical Properties