1979157-17-9

1979157-17-9 structure

Name: EZH2-IN-14
Chemical Name: EZH2-IN-14
CAS Number: 1979157-17-9
Molecular Formula: C₃₁H₃₉N₇O₂
Molecular Weight: 541.69
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2023-01-15 10:03:13
Modify Date: 2024-04-02 22:32:17
EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1].

Name	EZH2-IN-14

Description	EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. EZH2-IN-14 inhibits the methyltransferase activity of EZH2/PRC2 (that is, reducing H3K27me3). EZH2-IN-14 shows >200-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
In Vitro	EZH2-IN-14 (C24) 有效减少H3K27me3 和 H3K27me2 蛋白水平，但对 MDA-MB-468 细胞中 EZH2 蛋白水平影响不大[1]。 Cell Viability Assay[1] Cell Line: MDA-MB-468 cells Concentration: 4 μM Incubation Time: 6 hours, 12 hours, 24 hours, 48 hours Result: Reduced the H3K27me3 and H3K27me2 marks.
References	[1]. Anqi Ma, et al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16(2):214-222.

Molecular Formula	C₃₁H₃₉N₇O₂
Molecular Weight	541.69