Solriamfetol hydrochloride

Modify Date: 2024-01-11 15:13:16

Solriamfetol hydrochloride structure	Common Name	Solriamfetol hydrochloride
	CAS Number	178429-65-7	Molecular Weight	230.691
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₅ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Solriamfetol hydrochloride

Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2].

Name	K7RO88SP7A
Synonym	More Synonyms

Description	Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1]
In Vitro	Solriamfetol hydrochloride (JZP-110 hydrochloride) has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1].
In Vivo	Solriamfetol hydrochloride (JZP-110 hydrochloride; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1]. Solriamfetol hydrochloride (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1]. solriamfetol hydrochloride (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1]. Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1] Dosage: 10 and 30 mg/kg Administration: S.c.; eight consecutive 50-minute Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively.
References	[1]. Baladi MG, et al. Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor. J Pharmacol Exp Ther. 2018 Aug;366(2):367-376. [2]. Yang J, et al. Solriamfetol for the treatment of excessive daytime sleepiness associated with narcolepsy. Expert Rev Clin Pharmacol. 2019 Aug;12(8):723-728.

Molecular Formula	C₁₀H₁₅ClN₂O₂
Molecular Weight	230.691
Exact Mass	230.082199

K7RO88SP7A

(2R)-2-Amino-3-phenylpropyl carbamate hydrochloride (1:1)

Benzenepropanol, β-amino-, carbamate (ester), (βR)-, hydrochloride (1:1)

Solriamfetol hydrochloride

Use of Solriamfetol hydrochloride

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Solriamfetol hydrochloride Biological Activity

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