2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

Modify Date: 2024-01-11 11:57:07

2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine Structure
2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine structure
Common Name 2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine
CAS Number 174221-86-4 Molecular Weight 545.58
Density N/A Boiling Point N/A
Molecular Formula C30H31N3O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine


2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[(2R,3R,4S,5R)-3-amino-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C30H31N3O7
Molecular Weight 545.58
Exact Mass 545.21600
PSA 138.29000
LogP 3.26070

 Synthetic Route

 Synonyms

5'-DMT-protected 2'-amino-2'-deoxyuridine
5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine
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