2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

Names

[ CAS No. ]:
174221-86-4

[ Name ]:
2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine

[Synonym ]:
5'-DMT-protected 2'-amino-2'-deoxyuridine
5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine

Biological Activity

[Description]:

2′-Amino-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H31N3O7

[ Molecular Weight ]:
545.58

[ Exact Mass ]:
545.21600

[ PSA ]:
138.29000

[ LogP ]:
3.26070

Synthetic Route

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