JZP-MA-11
Modify Date: 2024-04-04 22:15:36
JZP-MA-11 structure
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Common Name | JZP-MA-11 | ||
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| CAS Number | 1672691-50-7 | Molecular Weight | 336.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H17FN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JZP-MA-11JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1]. |
| Name | JZP-MA-11 |
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| Description | JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP)[1]. |
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| Related Catalog | |
| In Vitro | JZP-MA-11 (10 μM) 对表达 CB1 或 CB2 的 HEK293 细胞中 毛喉素 (HY-15371) 刺激的 cAMP 没有影响[1]。 |
| In Vivo | JZP-MA-11 (1.5 mg/kg; 静脉给药; 示踪剂注射前 20 分钟) 导致大脑、肝脏、心脏和肾脏等富含 ABHD6 的器官的放射性摄取减少[1]。 Animal Model: C57BL6 mice (female, 10-12-week-old)[1] Dosage: 1.5 mg/kg Administration: IV; 20 min before tracer injection Result: Resulted in a decrease in radioactivity uptake in ABHD6-rich organs such as, brain, liver, heart, and kidneys. |
| References |
| Molecular Formula | C15H17FN4O2S |
|---|---|
| Molecular Weight | 336.38 |