Pep19-2.5
Modify Date: 2024-09-18 08:41:57
Pep19-2.5 structure
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Common Name | Pep19-2.5 | ||
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| CAS Number | 1322711-38-5 | Molecular Weight | 2712.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C135H187N37O22S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pep19-2.5Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1]. |
| Name | Pep19-2.5 |
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| Description | Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1]. |
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| Related Catalog | |
| In Vivo | Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2]. Animal Model: Sepsis model in male New Zealand rabbits (2-2.5 kg)[2] Dosage: 5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL Administration: Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min) Result: Killed bacteria and eliminates bacteremia 30 min post challenge; Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge; Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α); And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge. |
| Molecular Formula | C135H187N37O22S |
|---|---|
| Molecular Weight | 2712.23 |