Pep19-2.5

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1].

Research Areas >> Inflammation/Immunology

Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2]. Animal Model: Sepsis model in male New Zealand rabbits (2-2.5 kg)[2] Dosage: 5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL Administration: Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min) Result: Killed bacteria and eliminates bacteremia 30 min post challenge; Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge; Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α); And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.