BaquilopriM-D6

Modify Date: 2024-01-20 17:26:20

BaquilopriM-D6 Structure
BaquilopriM-D6 structure
Common Name BaquilopriM-D6
CAS Number 1228182-50-0 Molecular Weight 314.42
Density N/A Boiling Point N/A
Molecular Formula C17H14D6N6 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of BaquilopriM-D6


Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].

 Names

Name 5-[[8-[bis(trideuteriomethyl)amino]-7-methylquinolin-5-yl]methyl]pyrimidine-2,4-diamine
Synonym More Synonyms

 BaquilopriM-D6 Biological Activity

Description Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lewicki J, et, al. Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats. Res Vet Sci. 1995 May;58(3):268-71.

[3]. White DG, et, al. Comparison of danofloxacin with baquiloprim/sulphadimidine for the treatment of experimentally induced Escherichia coli diarrhoea in calves. Vet Rec. 1998 Sep 5;143(10):273-6.

 Chemical & Physical Properties

Molecular Formula C17H14D6N6
Molecular Weight 314.42
Exact Mass 314.21300
PSA 95.41000
LogP 2.01460
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 22-36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport

 Synonyms

5-{[8-(Dimethylamino-d6)-7-methyl-5-quinolinyl]methyl}-2,4-pyrimidinediamine
Baquiloprim-d6