Thymidine 3',5'-diphosphate tetrasodium structure
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Common Name | Thymidine 3',5'-diphosphate tetrasodium | ||
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CAS Number | 118675-87-9 | Molecular Weight | 490.12 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H12N2Na4O11P2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Thymidine 3',5'-diphosphate tetrasodiumThymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) tetrasodium is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit). Thymidine 3',5'-diphosphate tetrasodium exhibits anti-tumor efficacy in vivo[1]. |
Name | Thymidine 3',5'-diphosphate tetrasodium |
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Description | Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) tetrasodium is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit). Thymidine 3',5'-diphosphate tetrasodium exhibits anti-tumor efficacy in vivo[1]. |
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Related Catalog | |
Target |
Staphylococcal nuclease and tudor domain containing 1, SND1[1] |
In Vitro | Thymidine 3',5'-diphosphate tetrasodium (200 µM;18 h) 通过抑制葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1) 酶活性显著降低 WT 和 Alb/SND1 (特异性过表达 SND1 转基因小鼠) 肝细胞中 p65 表达水平和 p65 核易位。Thymidine 3',5'-diphosphate tetrasodium 抑制了 WT 和 Alb/SND1 肝细胞的球形形成[1]。 |
In Vivo | Thymidine 3',5'-diphosphate tetrasodium (0.8 mg/kg 或 1.6 mg/kg;腹腔注射或静脉注射;每周两次持续四周) 显著抑制 WT B6/CBA 小鼠中人肝癌的异种移植[1]。 Thymidine 3',5'-diphosphate tetrasodium (0.8, 0.16 和 0.32 mg/kg;皮下注射;每周两次持续四周) 抑制成年雄性 NSG 小鼠中肿瘤增殖、炎症反应和肿瘤起源细胞 (TIC) 标志物的表达。Thymidine 3',5'-diphosphate tetrasodium 上调了凋亡和选择性肿瘤抑制基因的表达[1]。 |
References |
Molecular Formula | C10H12N2Na4O11P2 |
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Molecular Weight | 490.12 |