2-Ketoglutaric acid-d6

Modify Date: 2024-01-09 12:53:54

2-Ketoglutaric acid-d6 structure	Common Name	2-Ketoglutaric acid-d6
	CAS Number	1173021-86-7	Molecular Weight	152.13500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅D₆O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of 2-Ketoglutaric acid-d6

2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

Name	dideuterio 2,2,3,3-tetradeuterio-4-oxopentanedioate
Synonym	More Synonyms

Description	2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662.

Molecular Formula	C₅D₆O₅
Molecular Weight	152.13500
Exact Mass	152.05900
PSA	91.67000

2-Ketoglutaric acid-d6 MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport

|A-Ketopentanoic acid-d6

2-Ketoglutaric acid-d6

2-Ketopentanedioic acid-d6

|A-Ketoglutaric acid-d6

2-Ketoglutaric acid-d6

Use of 2-Ketoglutaric acid-d6

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2-Ketoglutaric acid-d6 Biological Activity

Chemical & Physical Properties

MSDS

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