trans-Isoferulic acid-d3

Modify Date: 2024-03-26 09:27:59

trans-Isoferulic acid-d3 Structure
trans-Isoferulic acid-d3 structure
Common Name trans-Isoferulic acid-d3
CAS Number 1028203-97-5 Molecular Weight 197.20200
Density N/A Boiling Point N/A
Molecular Formula C10H7D3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of trans-Isoferulic acid-d3


trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].

 Names

Name 3-Hydroxy-4-methoxycinnamic Acid-d3 (Isoferulic Acid-d3)
Synonym More Synonyms

 trans-Isoferulic acid-d3 Biological Activity

Description trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of <i>Clematis florida var. plena</i>. Nat Prod Res. 2019 Oct;33(20):2925-2931.  

[3]. Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan18(1):203-11.  

 Chemical & Physical Properties

Molecular Formula C10H7D3O4
Molecular Weight 197.20200
Exact Mass 197.07700
PSA 66.76000
LogP 1.49860

 Synonyms

(E)-3-[3-hydroxy-4-(trideuteriomethoxy)phenyl]prop-2-enoic acid