Chloroquinoxaline sulfonamide

Modify Date: 2024-01-18 16:18:52

Chloroquinoxaline sulfonamide structure	Common Name	Chloroquinoxaline sulfonamide
	CAS Number	97919-22-7	Molecular Weight	334.78100
	Density	1.569g/cm3	Boiling Point	576.3ºC at 760mmHg
	Molecular Formula	C₁₄H₁₁ClN₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	302.3ºC

Use of Chloroquinoxaline sulfonamide

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle[1]. Antitumor activity[2].

Name	4-amino-N-(5-chloroquinoxalin-2-yl)benzenesulfonamide
Synonym	More Synonyms

Description	Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle[1]. Antitumor activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection
Target	topoisomerase II alpha topoisomerase II beta
In Vitro	The Chloroquinoxaline sulfonamide IC50 for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links[1]. Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used[2]. Cell Proliferation Assay[2] Cell Line: B16 murine melanoma cells Concentration: 10 μM, 100 μM, 1 mM Incubation Time: 24, 48, 72 hours Result: Inhibited proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) were used.
References	[1]. Gao H, et al. Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer Res. 2000 Nov 1;60(21):5937-40. [2]. Branda RF, et al. Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells. Biochem Pharmacol. 1988 Dec 1;37(23):4557-64.

Density	1.569g/cm3
Boiling Point	576.3ºC at 760mmHg
Molecular Formula	C₁₄H₁₁ClN₄O₂S
Molecular Weight	334.78100
Flash Point	302.3ºC
Exact Mass	334.02900
PSA	106.35000
LogP	4.40120
Index of Refraction	1.734

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA9467000

CHEMICAL NAME :: Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-

CAS REGISTRY NUMBER :: 97919-22-7

BEILSTEIN REFERENCE NO. :: 0312075

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H11-Cl-N4-O2-S

MOLECULAR WEIGHT :: 334.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Skin and Appendages - primary irritation (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-128658

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 607 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Skin and Appendages - primary irritation (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-128658

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Skin and Appendages - primary irritation (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-128658 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 600 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB87-128658

HS Code	2935009090

1,2-Diamino-3-c...

CAS#:21745-41-5

Chloroquinoxali...

CAS#:97919-22-7

Literature: Wolf et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 6,7

4-Acetamidobenz...

CAS#:121-60-8

Chloroquinoxali...

CAS#:97919-22-7

Literature: Wolf et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 6,7

2,5-dichloroqui...

CAS#:55687-05-3

Chloroquinoxali...

CAS#:97919-22-7

Literature: Wolf et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 6,7

Precursor 3
CAS#:55687-05-3 2,5-dichloroqui... CAS#:21745-41-5 1,2-Diamino-3-c... CAS#:121-60-8 4-Acetamidobenz...
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Chlorsulfaquinoxaline

chloroquinoxaline sulfonamide

Sulfanilsaeure-(5-chlor-chinoxalin-2-ylamid)

4-Amino-N-(5-chloro-2-quinoxalinyl)benzenesulfonamide

5-Chloroquinoxaline-2-sulfanilamide

sulfanilic acid-(5-chloro-quinoxalin-2-ylamide)

DC Chemicals Limited
China
Product Name: Chloroquinoxaline sulfonamide
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenesulfonamide,4-amino-N-(5-chloro-2-quinoxalinyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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