Metaphit

Modify Date: 2024-02-04 18:22:55

Metaphit Structure
Metaphit structure
Common Name Metaphit
CAS Number 96316-00-6 Molecular Weight 300.46
Density 1.12g/cm3 Boiling Point 433.7ºC at 760mmHg
Molecular Formula C18H24N2S Melting Point N/A
MSDS N/A Flash Point 216.1ºC

 Use of Metaphit


Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].

 Names

Name Metaphit,1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine

 Metaphit Biological Activity

Description Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].
Related Catalog
References

[1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74  

[2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22.  

 Chemical & Physical Properties

Density 1.12g/cm3
Boiling Point 433.7ºC at 760mmHg
Molecular Formula C18H24N2S
Molecular Weight 300.46
Flash Point 216.1ºC
Exact Mass 396.15400
PSA 110.44000
LogP 5.58890
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