Metaphit

Modify Date: 2025-12-02 12:07:37

Metaphit structure	Common Name	Metaphit
	CAS Number	96316-00-6	Molecular Weight	300.46
	Density	1.12g/cm3	Boiling Point	433.7ºC at 760mmHg
	Molecular Formula	C₁₈H₂₄N₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	216.1ºC

Use of Metaphit

Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].

Name	Metaphit,1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine

Description	Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74 [2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74

[2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22.

Density	1.12g/cm3
Boiling Point	433.7ºC at 760mmHg
Molecular Formula	C₁₈H₂₄N₂S
Molecular Weight	300.46
Flash Point	216.1ºC
Exact Mass	396.15400
PSA	110.44000
LogP	5.58890
InChIKey	FGSGBQAQSPSRJK-UHFFFAOYSA-N
SMILES	S=C=Nc1cccc(C2(N3CCCCC3)CCCCC2)c1

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