96316-00-6

96316-00-6 structure

Name: Metaphit
Chemical Name: Metaphit,1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine
CAS Number: 96316-00-6
Molecular Formula: C₁₈H₂₄N₂S
Molecular Weight: 300.46
Catalog: Research Areas Neurological Disease
Create Date: 2017-10-16 06:15:55
Modify Date: 2024-02-04 18:22:55
Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].

Name	Metaphit,1-(1-(3-Isothiocyanato)phenyl)cyclohexylpiperidine

Description	Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates[1]. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. E D French, et al. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors. Eur J Pharmacol. 1987 Aug 21;140(3):267-74 [2]. M F Rafferty, et al. A specific acylating agent for the [3H]phencyclidine receptors in rat brain. FEBS Lett. 1985 Feb 25;181(2):318-22.