Senkyunolide I

Modify Date: 2024-01-02 11:01:27

Senkyunolide I structure	Common Name	Senkyunolide I
	CAS Number	94596-28-8	Molecular Weight	224.253
	Density	1.3±0.1 g/cm3	Boiling Point	444.8±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	175.1±22.2 °C

Use of Senkyunolide I

Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].

Name	Senkyunolide I
Synonym	More Synonyms

Description	Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
References	[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6. [2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Inflammation/Immunology

References

[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6.

[2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Density	1.3±0.1 g/cm3
Boiling Point	444.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₆O₄
Molecular Weight	224.253
Flash Point	175.1±22.2 °C
Exact Mass	224.104858
PSA	66.76000
LogP	1.04
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.571
Storage condition	2-8℃