94596-28-8

94596-28-8 structure

Name: Senkyunolide I
Chemical Name: Senkyunolide I
CAS Number: 94596-28-8
Molecular Formula: C₁₂H₁₆O₄
Molecular Weight: 224.253
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-10-03 19:37:35
Modify Date: 2025-08-23 16:03:15
Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].

Name	Senkyunolide I
Synonyms	seneciphyllin 1(3H)-Isobenzofuranone, 3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6S,7S)- SenkyunolideI (3Z,6S,7S)-3-Butylidene-6,7-dihydroxy-4,5,6,7-tetrahydro-2-benzofuran-1(3H)-one UNII:12PJ07292V

Description	Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
References	[1]. Wang YH, et al. Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. J Pharm Pharmacol. 2011 Feb;63(2):261-6. [2]. Hu Y, et al. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res. 2015 Apr 24;1605:39-48.

Hazard Codes	Xi