Cromakalim
Cromakalim structure
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Common Name | Cromakalim | ||
|---|---|---|---|---|
| CAS Number | 94470-67-4 | Molecular Weight | 286.33 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 482.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H20N2O3S | Melting Point | 242-244ºC | |
| MSDS | USA | Flash Point | 245.5±28.7 °C | |
Use of CromakalimCromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1]. |
| Name | (±)-Cromakalim |
|---|---|
| Synonym | More Synonyms |
| Description | Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 482.3±45.0 °C at 760 mmHg |
| Melting Point | 242-244ºC |
| Molecular Formula | C16H20N2O3S |
| Molecular Weight | 286.33 |
| Flash Point | 245.5±28.7 °C |
| Exact Mass | 286.131744 |
| PSA | 73.56000 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| Precursor 0 | |
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| DownStream 3 | |
CAS#:121021-88-3
CAS#:89080-71-7
CAS#:94535-50-9|
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Pharmacology 89(5-6) , 327-32, (2012) The relaxant mechanisms of nicorandil were examined by comparing its effects with those of sodium nitroprusside and cromakalim in bovine tracheal smooth muscle. In preparations contracted with methach... |
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CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R1003-10, (2012) Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hy... |
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Phasic activity of urinary bladder smooth muscle in the streptozotocin-induced diabetic rat: effect of potassium channel modulators.
Eur. J. Pharmacol. 660(2-3) , 431-7, (2011) Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+)... |
| (3R,4S)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromanecarbonitrile |
| (3R,4S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-chromene-6-carbonitrile |
| 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)- |
| (+)-Cromakalim |