2-Iodomelatonin

Modify Date: 2025-08-24 17:05:47

2-Iodomelatonin structure	Common Name	2-Iodomelatonin
	CAS Number	93515-00-5	Molecular Weight	358.17500
	Density	1.63g/cm3	Boiling Point	574.5ºC at 760mmHg
	Molecular Formula	C₁₃H₁₅IN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	301.3ºC

Use of 2-Iodomelatonin

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

Name	N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Synonym	More Synonyms

Description	2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor
In Vitro	2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells[2]. Cell Viability Assay[2] Cell Line: Mutant htt ST14A cell Concentration: 0 μM; 1 μM; 5 μM; 7.5 μM Incubation Time: 18 hours Result: Inhibited mutant htt ST14A cell death.
References	[1]. Tomkinson A, et al. A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol. 2001 May 1;166(9):5792-800. [2]. Wang X, et al. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.J Neurosci. 2011 Oct 12;31(41):14496-507.

Density	1.63g/cm3
Boiling Point	574.5ºC at 760mmHg
Molecular Formula	C₁₃H₁₅IN₂O₂
Molecular Weight	358.17500
Flash Point	301.3ºC
Exact Mass	358.01800
PSA	54.12000
LogP	2.85060
Index of Refraction	1.654
InChIKey	FJDDSMSDZHURBJ-UHFFFAOYSA-N
SMILES	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC4376000

CHEMICAL NAME :: Acetamide, N-(2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl)-

CAS REGISTRY NUMBER :: 93515-00-5

LAST UPDATED :: 199406

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H15-I-N2-O2

MOLECULAR WEIGHT :: 358.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 53,1357,1993

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 53,1357,1993

WGK Germany	3
RTECS	AC4376000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

ML2

Tocris-0737

IODOMELATONIN

Lopac-I-1899

2-Iodomelatonin

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Shanghai Nianxing Industrial Co., Ltd
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: 2-Iodomelatonin
Price: ￥Inquiry/1g
Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-IODOMELATONIN
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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2-Iodomelatonin

Use of 2-Iodomelatonin

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2-Iodomelatonin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.