FiVe1
Modify Date: 2025-10-22 17:24:38
FiVe1 structure
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Common Name | FiVe1 | ||
|---|---|---|---|---|
| CAS Number | 932359-76-7 | Molecular Weight | 359.254 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FiVe1FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes. |
| Name | FiVe1 |
|---|
| Description | FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes. |
|---|---|
| References | References 1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. View Related Products by Target Microtubule/Tubulin |
| Molecular Formula | C18H16Cl2N4 |
|---|---|
| Molecular Weight | 359.254 |
| InChIKey | DZGXRHIQXADSDH-UHFFFAOYSA-N |
| SMILES | Clc1cccc(N2CCN(c3cnnc4c(Cl)cccc34)CC2)c1 |