932359-76-7
932359-76-7 structure
- Name: FiVe1
- Chemical Name: FiVe1
- CAS Number: 932359-76-7
- Molecular Formula: C18H16Cl2N4
- Molecular Weight: 359.254
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2020-01-20 13:59:57
- Modify Date: 2025-10-22 17:24:38
-
FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.
| Name | FiVe1 |
|---|
| Description | FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes. |
|---|---|
| References | References 1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. View Related Products by Target Microtubule/Tubulin |
| Molecular Formula | C18H16Cl2N4 |
|---|---|
| Molecular Weight | 359.254 |