FiVe1

Names

[ Name ]:
FiVe1

Biological Activity

[Description]:

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.

[References]

References 1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. View Related Products by Target Microtubule/Tubulin

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆Cl₂N₄

[ Molecular Weight ]:
359.254

Related Compounds

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