5-amino-2H-isoquinolin-1-one,hydrochloride
5-amino-2H-isoquinolin-1-one,hydrochloride structure
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Common Name | 5-amino-2H-isoquinolin-1-one,hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 93117-07-8 | Molecular Weight | 196.63400 | |
| Density | N/A | Boiling Point | 481ºC at 760 mmHg | |
| Molecular Formula | C9H9ClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 244.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
| Name | 5-amino-2H-isoquinolin-1-one,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Boiling Point | 481ºC at 760 mmHg |
|---|---|
| Molecular Formula | C9H9ClN2O |
| Molecular Weight | 196.63400 |
| Flash Point | 244.7ºC |
| Exact Mass | 196.04000 |
| PSA | 59.14000 |
| LogP | 2.90580 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933790090 |
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.
PLoS ONE 8(2) , e55883, (2013) Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here,... |
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Inhibition of matrix metalloproteinase-2 by PARP inhibitors.
Biochem. Biophys. Res. Commun. 387 , 646-50, (2009) Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidati... |
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Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.
Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006) Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in m... |
| 5-AIQ hydrochloride |
| 5-aminoisoquinolin-1-one hydrochloride |
| 5-Aminoisoquinolin-1(2H)-one hydrochloride |
| 5-Aminoisoquinolinone hydrochloride |