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5-amino-2H-isoquinolin-1-one,hydrochloride

Names

[ CAS No. ]:
93117-07-8

[ Name ]:
5-amino-2H-isoquinolin-1-one,hydrochloride

[Synonym ]:
5-AIQ hydrochloride
5-aminoisoquinolin-1-one hydrochloride
5-Aminoisoquinolin-1(2H)-one hydrochloride
5-Aminoisoquinolinone hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
481ºC at 760 mmHg

[ Molecular Formula ]:
C9H9ClN2O

[ Molecular Weight ]:
196.63400

[ Flash Point ]:
244.7ºC

[ Exact Mass ]:
196.04000

[ PSA ]:
59.14000

[ LogP ]:
2.90580

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933790090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

PLoS ONE 8(2) , e55883, (2013)

Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here,...

Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

Biochem. Biophys. Res. Commun. 387 , 646-50, (2009)

Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidati...

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

Biochem. Biophys. Res. Commun. 350 , 1056-62, (2006)

Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in m...


More Articles


Related Compounds

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