ecamsule

Modify Date: 2024-01-02 12:09:56

ecamsule Structure
ecamsule structure
Common Name ecamsule
CAS Number 92761-26-7 Molecular Weight 562.695
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C28H34O8S2 Melting Point 255° (dec)
MSDS Chinese USA Flash Point N/A
Symbol GHS05
GHS05
Signal Word Danger

 Use of ecamsule


Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].

 Names

Name Ecamsule
Synonym More Synonyms

 ecamsule Biological Activity

Description Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2].
Related Catalog
In Vitro Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment[1]. . Ecamsule counteractes UV and AAPH induced ROS-formation[1]. .The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%[1]. . Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1].
References

[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.

[2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 255° (dec)
Molecular Formula C28H34O8S2
Molecular Weight 562.695
Exact Mass 562.169495
PSA 159.64000
LogP 1.35
Index of Refraction 1.631

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338 + P310
Hazard Codes Xi: Irritant;
Risk Phrases 41
Safety Phrases 26-39
RIDADR NONH for all modes of transport

 Synonyms

3,3'-(1,4-Phenylenedimethylidyne)bis[7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonic Acid]
Mexoryl SX
3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid)
Terephthalylidene-3,3'-dicamphor-10,10'-disulfonic Acid
(1,4-Phenylene bis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo [2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid
(1,4-Phenylenebis{(Z)methylylidene[(3Z)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl-3-ylidene]})dimethanesulfonic acid
Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 3,3'-[1,4-phenylenedi(Z)methylidyne]bis[7,7-dimethyl-2-oxo-, (3Z)-
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